volker briken headshot
Contact Info
Office: 3110 Bioscience Research Bldg
Phone: 301-405-0289
Briken Lab
Volker Briken
Professor

Graduate Program Affiliations

  • BISI-Molecular & Cellular Biology (MOCB)
  • BISI-Computational Biology, Bioinformatics, & Genomics (CBBG)

Research Interests

Mycobacterium tuberculosis, Host-Pathogen Interactions, Apoptosis, Lipid and Protein Antigen Presentation, Virulence Genes

Education

  • Ph.D., University of Paris (France), 1998

All Publications

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Latest Publications

Shuster M,Lyu Z,Augenstreich J,Mathur S,Ganesh A,Ling J,Briken V
Salmonella Typhimurium infection inhibits macrophage IFNβ signaling in a TLR4-dependent manner.
Infect Immun. 2024 Sep 13;:e0009824. doi: 10.1128/iai.00098-24. Epub 2024 Sep 13
Rastogi S,Ganesh A,Briken V
Mycobacterium tuberculosis Utilizes Serine/Threonine Kinase PknF to Evade NLRP3 Inflammasome-driven Caspase-1 and RIPK3/Caspase-8 Activation in Murine Dendritic Cells.
J Immunol. 2024 Sep 1;213(5):690-699. doi: 10.4049/jimmunol.2300753. Epub
Augenstreich J,Poddar A,Belew AT,El-Sayed NM,Briken V
da_Tracker: Automated workflow for high throughput single cell and single phagosome tracking in infected cells.
Biol Open. 2024 Aug 23;:. pii: bio.060555. doi: 10.1242/bio.060555. Epub 2024 Aug 23
Augenstreich J,Poddar A,Belew AT,El-Sayed NM,Briken V
da_Tracker: Automated workflow for high throughput single cell and single phagosome tracking in infected cells.
bioRxiv. 2024 Apr 11;:. pii: 2024.04.10.588863. doi: 10.1101/2024.04.10.588863. Epub 2024 Apr 11
Shuster M,Lyu Z,Augenstreich J,Mathur S,Ganesh A,Ling J,Briken V
Salmonella Typhimurium infection inhibits macrophage IFNβ signaling in a TLR4-dependent manner.
bioRxiv. 2024 Mar 5;:. pii: 2024.03.05.583530. doi: 10.1101/2024.03.05.583530. Epub 2024 Mar 5
Augenstreich J,Shuster M,Fan Y,Lyu Z,Ling J,Briken V
BBQ methods: streamlined workflows for bacterial burden quantification in infected cells by confocal microscopy.
Biol Open. 2024 Jan 15;13(1):. doi: 10.1242/bio.060189. Epub 2024 Jan 22
Allen CNS,Banks DA,Shuster M,Vogel SN,O'Connor TJ,Briken V
Legionella pneumophila inhibits type I interferon signaling to avoid cell-intrinsic host cell defense.
Infect Immun. 2023 Nov 16;91(11):e0036523. doi: 10.1128/iai.00365-23. Epub 2023 Oct 16
Lyu Z,Villanueva P,O'Malley L,Murphy P,Augenstreich J,Briken V,Singh A,Ling J
Genome-wide screening reveals metabolic regulation of stop-codon readthrough by cyclic AMP.
Nucleic Acids Res. 2023 Oct 13;51(18):9905-9919. doi: 10.1093/nar/gkad725. Epub
Augenstreich J,Shuster M,Fan Y,Lyu Z,Ling J,Briken V
BBQ methods: Streamlined workflows for Bacterial Burden Quantification in infected cells by confocal microscopy.
bioRxiv. 2023 Oct 2;:. pii: 2023.10.01.560379. doi: 10.1101/2023.10.01.560379. Epub 2023 Oct 2
Brockett AT,Xue W,King D,Deng CL,Zhai C,Shuster M,Rastogi S,Briken V,Roesch MR,Isaacs L
Pillar[6]MaxQ: A Potent Supramolecular Host for In Vivo Sequestration of Methamphetamine and Fentanyl.
Chem. 2023 Apr 13;9(4):881-900. doi: 10.1016/j.chempr.2022.11.019. Epub 2022 Dec 15
Rastogi S,Evavold CL,Briken V
Putting the p(hosphor) in pyroptosis.
Cell Host Microbe. 2022 Dec 14;30(12):1650-1652. doi: 10.1016/j.chom.2022.11.010. Epub
DiMaggio D,Brockett AT,Shuster M,Murkli S,Zhai C,King D,O'Dowd B,Cheng M,Brady K,Briken V,Roesch MR,Isaacs L
Anthracene-Walled Acyclic CB[n] Receptors: in vitro and in vivo Binding Properties toward Drugs of Abuse.
ChemMedChem. 2022 May 18;17(10):e202200046. doi: 10.1002/cmdc.202200046. Epub 2022 Mar 15
Rastogi S,Briken V
Interaction of Mycobacteria With Host Cell Inflammasomes.
Front Immunol. 2022;13:791136. doi: 10.3389/fimmu.2022.791136. Epub 2022 Feb 14
Brockett AT,Deng C,Shuster M,Perera S,DiMaggio D,Cheng M,Murkli S,Briken V,Roesch MR,Isaacs L
In Vitro and In Vivo Sequestration of Methamphetamine by a Sulfated Acyclic CB[n]-Type Receptor.
Chemistry. 2021 Dec 9;27(69):17476-17486. doi: 10.1002/chem.202102919. Epub 2021 Oct 27
Rastogi S,Ellinwood S,Augenstreich J,Mayer-Barber KD,Briken V
Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF.
PLoS Pathog. 2021 Jul;17(7):e1009712. doi: 10.1371/journal.ppat.1009712. Epub 2021 Jul 29
Murkli S,Klemm J,Brockett AT,Shuster M,Briken V,Roesch MR,Isaacs L
In Vitro and In Vivo Sequestration of Phencyclidine by Me(4) Cucurbit[8]uril*.
Chemistry. 2021 Feb 10;27(9):3098-3105. doi: 10.1002/chem.202004380. Epub 2021 Jan 19
Augenstreich J,Briken V
Host Cell Targets of Released Lipid and Secreted Protein Effectors of Mycobacterium tuberculosis.
Front Cell Infect Microbiol. 2020;10:595029. doi: 10.3389/fcimb.2020.595029. Epub 2020 Oct 23
Behar SM,Briken V
Apoptosis inhibition by intracellular bacteria and its consequence on host immunity.
Curr Opin Immunol. 2019 Oct;60:103-110. doi: 10.1016/j.coi.2019.05.007. Epub 2019 Jun 19
Banks DA,Ahlbrand SE,Hughitt VK,Shah S,Mayer-Barber KD,Vogel SN,El-Sayed NM,Briken V
Mycobacterium tuberculosis Inhibits Autocrine Type I IFN Signaling to Increase Intracellular Survival.
J Immunol. 2019 Apr 15;202(8):2348-2359. doi: 10.4049/jimmunol.1801303. Epub 2019 Mar 4
Samanta SK,Moncelet D,Vinciguerra B,Briken V,Isaacs L
Metal Organic Polyhedra: A Click-and-Clack Approach Toward Targeted Delivery.
Helv Chim Acta. 2018 Jun;101(6):. pii: e1800057. doi: 10.1002/hlca.201800057. Epub 2018 May 6