Vincent Lee




Office Phone: (301) 405-9397

Fax: (301) 314-1248

Office Address: 3114 Biosciences Research Building




BSCI412 Microbial Genetics

CBMG688M Microbial Genetics


graduate program affiliations

  • BISI - Molecular & Cellular Biology (MOCB)

research interests

Host-pathogen interactions, molecular mechanisms of pathogenesis for Pseudomonas aeruginosa, allosteric regulation of molecular complexes, bacterial signal transduction and small molecular inhibitors.


recent publicatons

Kim, S.K., Lormand, J.D., Weiss, C.A., Eger, K.A., Turdiev, H., Turdiev, A., Winkler, W.C., Sondermann, H., Lee, V.T. 2019. A dedicated diribonucleotidase resolves a key bottleneck for the terminal step of RNA degradation. Elife. Jun 21;8. pii: e46313. PMID: 31225796


Orr, M.W., Weiss, C.A., Severin, G.B., Turdiev, H., Kim, S.-K., Liu, K., Tu, B.P., Waters, C.M., Winkler, W.C., Lee V.T. 2018. A subset of exoribonucleases serve as degradative enzymes for pGpG in c-di-GMP signaling. J. Bacteriol. pii: JB.00300-18. PMID: 30249708


Cole, S.J., Hall, C.L., Schniederberend, M., Farrow III, J.M., Goodson, J.R., Pesci, E.C., Kazmierczak, B.I., Lee V.T. 2018. Host suppression of quorum sensing during catheter associated urinary tract infections. Nature Comm. 9(1):4436. PMID: 30361690


Zhou E., Seminara, A.B., Kim, S.K., Hall, C.L., Wang Y, Lee V.T. 2017. Thiol-benzo-triazolo-quinazolinone Inhibits Alg44 Binding to c-di-GMP and Reduces Alginate Production by Pseudomonas aeruginosa. ACS Chem Biol. 12(12):3076-3085. doi: 10.1021/acschembio.7b00826. PMID: 29091392


Roelofs, K.G., Jones, C.J., Helman, S.H., Shang, X., Orr, M.W., Goodson, J.R., Galperin, M.Y., Yildiz, F.H., and Lee, V.T. 2015. Systematic identification of cyclic-di-GMP binding proteins in Vibrio cholerae reveals a novel class of cyclic-di-GMP-binding ATPases associated with Type II secretion systems. PLoS Pathogens. 11(10):e1005232. PMID: 26506097


Orr, M.W., Donaldson, G.P., Severin, G.B., Wang, J., Sintim, H.O., Waters, C.M., and Lee, V.T. 2015. Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover. Proc Natl Acad Sci U S A. 8;112(36):E5048-57. PMID: 26305945


Cole, S.J., Records, A.R., Orr, M.W., Linden, S.B., and Lee, V.T. 2014. Catheter-associated urinary tract infection by Pseudomonas aeruginosa is mediated by exopolysaccharide-independent biofilms. Infect Immun. 82(5):2048-58. doi: 10.1128/IAI.01652-14. PMID: 24595142


Lieberman, O.J., Orr, M.W., Wang, Y., and Lee, V.T. 2014. High-throughput screening using the differential radial capillary action of ligand assay identifies ebselen as an inhibitor of diguanylate cyclases. ACS Chemical Biology. 9(1):183-92. doi: 10.1021/cb400485k. PMID: 24134695


Corrigan, R.M., Campeotto, I., Jeganathan, T., Roelofs, K.G., Lee, V.T. and Gründling, A. 2013. Systematic identification of conserved bacterial c-di-AMP receptor proteins. Proc Natl Acad Sci U S A. 110(22):9084-9. PMID: 23671116 


Donaldson, G.P., Roelofs, K.G., Luo, Y., Sintim, H.O., Lee, V.T. 2011. A Rapid Assay for Affinity and Kinetics of Molecular Interactions with Nucleic Acids. Nucleic Acids Res. 40(7): e48. doi: 10.1093/nar/gkr1299. PMID: 22210888


Roelofs, K.G., Wang, J., Sintim, H.O., Lee, V.T. 2011. Differential radial capillary action of ligand assay for high-throughput detection of metabolite interactomes. Proc Natl Acad Sci U S A. 108(37):15528-33. PMID: 21876132 


Merighi, M., Lee, V.T., Hyodo, M., Hayakawa, Y., and Lory, S. 2007. The second messenger bis-(3’-5’)-cyclic-GMP and its PilZ domain-containing receptor Alg44 are required for alginate biosynthesis in Pseudomonas aeruginosa. Mol. Microbiol. 65: 876–895. PMID: 17645452


Lee, V.T., Matewish, J.M., Kessler, J.L. Hyodo, M., Hayakawa, Y., and Lory, S. 2007. A Cyclic-di-GMP Receptor Required for Bacterial Exopolysaccharide Production. Mol. Microbiol. 65: 1474-1484. PMID: 17824927 



Ph.D. - University of California - Los Angeles, 2000