Roy Mariuzza photo
Contact Info
Phone: 240-314-6243
IBBR webpage
Roy Mariuzza
Professor

Graduate Program Affiliations

  • BISI-Computational Biology, Bioinformatics, & Genomics (CBBG)
  • BISI-Molecular & Cellular Biology (MOCB)

Research Interests

Structural Immunology, Structure-function studies of antigen-antibody reactions, T cell activation by superantigens, Molecular mimicry in multiple sclerosis, Recognition of MHC class II-restricted tumor antigens by CD4 + T cells, Structural basis of MHC class I recognition by NK receptors, Microbial recognition by innate immune receptors, Assembly and structure of T cell signaling complexes.

Education

  • Ph.D., Biochemistry, University of Paris, 1986
  • M.S., Biochemistry, Yale University, 1978
  • B.S., Biochemistry, Yale University, 1978

All Publications

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Latest Publications

Adam K,Lipatova Z,Abdul Ghafoor Raja M,Mishra AK,Mariuzza RA,Workman CJ,Vignali DAA
Cutting Edge: LAG3 Dimerization Is Required for TCR/CD3 Interaction and Inhibition of Antitumor Immunity.
J Immunol. 2024 Jul 1;213(1):7-13. doi: 10.4049/jimmunol.2300673. Epub
Wu D,Yin R,Chen G,Ribeiro-Filho HV,Cheung M,Robbins PF,Mariuzza RA,Pierce BG
Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens.
bioRxiv. 2024 May 23;:. pii: 2024.05.21.595215. doi: 10.1101/2024.05.21.595215. Epub 2024 May 23
Mariuzza RA,Shahid S,Karade SS
The immune checkpoint receptor LAG3: Structure, function, and target for cancer immunotherapy.
J Biol Chem. 2024 May;300(5):107241. doi: 10.1016/j.jbc.2024.107241. Epub 2024 Mar 30
Sarratea MB,Alberti AS,Redolfi DM,Truant SN,Iannantuono Lopez LV,Bivona AE,Mariuzza RA,Fernández MM,Malchiodi EL
Zika virus NS4B protein targets TANK-binding kinase 1 and inhibits type I interferon production.
Biochim Biophys Acta Gen Subj. 2023 Dec;1867(12):130483. doi: 10.1016/j.bbagen.2023.130483. Epub 2023 Oct 4
Mariuzza RA,Wu D,Pierce BG
Structural basis for T cell recognition of cancer neoantigens and implications for predicting neoepitope immunogenicity.
Front Immunol. 2023;14:1303304. doi: 10.3389/fimmu.2023.1303304. Epub 2023 Nov 17
Choy C,Chen J,Li J,Gallagher DT,Lu J,Wu D,Zou A,Hemani H,Baptiste BA,Wichmann E,Yang Q,Ciffelo J,Yin R,McKelvy J,Melvin D,Wallace T,Dunn C,Nguyen C,Chia CW,Fan J,Ruffolo J,Zukley L,Shi G,Amano T,An Y,Meirelles O,Wu WW,Chou CK,Shen RF,Willis RA,Ko MSH,Liu YT,De S,Pierce BG,Ferrucci L,Egan J,Mariuzza R,Weng NP
SARS-CoV-2 infection establishes a stable and age-independent CD8(+) T cell response against a dominant nucleocapsid epitope using restricted T cell receptors.
Nat Commun. 2023 Oct 23;14(1):6725. doi: 10.1038/s41467-023-42430-z. Epub 2023 Oct 23
Mishra AK,Shahid S,Karade SS,Agnihotri P,Kolesnikov A,Hasan SS,Mariuzza RA
CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker.
Structure. 2023 Oct 5;31(10):1149-1157.e3. doi: 10.1016/j.str.2023.07.013. Epub 2023 Aug 23
Metcalf MC,Janus BM,Yin R,Wang R,Guest JD,Pozharski E,Law M,Mariuzza RA,Toth EA,Pierce BG,Fuerst TR,Ofek G
Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies.
Nat Commun. 2023 Jul 5;14(1):3980. doi: 10.1038/s41467-023-39659-z. Epub 2023 Jul 5
Wu D,Efimov GA,Bogolyubova AV,Pierce BG,Mariuzza RA
Structural insights into protection against a SARS-CoV-2 spike variant by T cell receptor diversity.
J Biol Chem. 2023 Apr;299(4):103035. doi: 10.1016/j.jbc.2023.103035. Epub 2023 Feb 17
Karade SS,Franco EJ,Rojas AC,Hanrahan KC,Kolesnikov A,Yu W,MacKerell AD Jr,Hill DC,Weber DJ,Brown AN,Treston AM,Mariuzza RA
Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum α-Glucosidase I with Anti-SARS-CoV-2 Activity.
J Med Chem. 2023 Feb 23;66(4):2744-2760. doi: 10.1021/acs.jmedchem.2c01750. Epub 2023 Feb 10
Rushdi MN,Pan V,Li K,Choi HK,Travaglino S,Hong J,Griffitts F,Agnihotri P,Mariuzza RA,Ke Y,Zhu C
Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity.
Nat Commun. 2022 Nov 17;13(1):7055. doi: 10.1038/s41467-022-34587-w. Epub 2022 Nov 17
Agnihotri P,Mishra AK,Agarwal P,Vignali KM,Workman CJ,Vignali DAA,Mariuzza RA
Epitope Mapping of Therapeutic Antibodies Targeting Human LAG3.
J Immunol. 2022 Oct 15;209(8):1586-1594. doi: 10.4049/jimmunol.2200309. Epub 2022 Sep 14
Fleishman SJ,Mariuzza RA
Editorial overview: Engineering and design.
Curr Opin Struct Biol. 2022 Aug;75:102437. doi: 10.1016/j.sbi.2022.102437. Epub 2022 Jul 21
Karade SS,Kolesnikov A,Treston AM,Mariuzza RA
Identification of Endoplasmic Reticulum α-Glucosidase I from a Thermophilic Fungus as a Platform for Structure-Guided Antiviral Drug Design.
Biochemistry. 2022 May 17;61(10):822-832. doi: 10.1021/acs.biochem.2c00092. Epub 2022 Apr 27
Wang R,Suzuki S,Guest JD,Heller B,Almeda M,Andrianov AK,Marin A,Mariuzza RA,Keck ZY,Foung SKH,Yunus AS,Pierce BG,Toth EA,Ploss A,Fuerst TR
Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate.
Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2112008119. doi: 10.1073/pnas.2112008119. Epub 2022 Mar 9
Wu D,Gowathaman R,Pierce BG,Mariuzza RA
T cell receptors employ diverse strategies to target a p53 cancer neoantigen.
J Biol Chem. 2022 Mar;298(3):101684. doi: 10.1016/j.jbc.2022.101684. Epub 2022 Feb 3
Wu D,Kolesnikov A,Yin R,Guest JD,Gowthaman R,Shmelev A,Serdyuk Y,Dianov DV,Efimov GA,Pierce BG,Mariuzza RA
Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.
Nat Commun. 2022 Jan 10;13(1):19. doi: 10.1038/s41467-021-27669-8. Epub 2022 Jan 10
Karade SS,Hill ML,Kiappes JL,Manne R,Aakula B,Zitzmann N,Warfield KL,Treston AM,Mariuzza RA
N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum α-Glucosidases I and II with Antiviral Activity.
J Med Chem. 2021 Dec 23;64(24):18010-18024. doi: 10.1021/acs.jmedchem.1c01377. Epub 2021 Dec 6
Andrianov AK,Marin A,Wang R,Chowdhury A,Agnihotri P,Yunus AS,Pierce BG,Mariuzza RA,Fuerst TR
In Vivo and In Vitro Potency of Polyphosphazene Immunoadjuvants with Hepatitis C Virus Antigen and the Role of Their Supramolecular Assembly.
Mol Pharm. 2021 Feb 1;18(2):726-734. doi: 10.1021/acs.molpharmaceut.0c00487. Epub 2020 Jun 23
Shahid S,Gao M,Travis Gallagher D,Pozharski E,Brinson RG,Keck ZY,Foung SKH,Fuerst TR,Mariuzza RA
Crystal Structure of a Bivalent Antibody Fab Fragment.
J Mol Biol. 2021 Jan 22;433(2):166714. doi: 10.1016/j.jmb.2020.11.013. Epub 2020 Nov 19

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