Margaret Scull headshot
Contact Info
Office: 3134 Bioscience Research Bldg
Phone: 301-405-6846
Margaret Scull
Associate Professor

Graduate Program Affiliations

  • BISI-Molecular & Cellular Biology (MOCB)

Research Interests

Airway biology; respiratory virus-host interactions; antiviral response in the airway; spatiotemporal dynamics of infection; tissue engineering and primary cell systems

Education & Positions

  • B.S., Duke University, 2001
  • Ph.D., The University of North Carolina, Chapel Hill, 2009
  • Postdoctoral research, The Rockefeller University, 2010-2016

All Publications

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Latest Publications

Goldstein ME,Ignacio MA,Loube JM,Whorton MR,Scull MA
Human Stimulator of Interferon Genes Promotes Rhinovirus C Replication in Mouse Cells In Vitro and In Vivo.
Viruses. 2024 Aug 10;16(8):. doi: 10.3390/v16081282. Epub 2024 Aug 10
Kaler L,Engle EM,Iverson E,Boboltz A,Ignacio MA,Rife M,Scull MA,Duncan G
Mucus physically restricts influenza A viral particle access to the epithelium.
bioRxiv. 2024 May 30;:. pii: 2023.08.14.553271. doi: 10.1101/2023.08.14.553271. Epub 2024 May 30
Razi N,Li W,Ignacio MA,Loube JM,Agostino EL,Zhu X,Scull MA,DeStefano JJ
Inhibition of SARS-CoV-2 infection in human airway epithelium with a xeno-nucleic acid aptamer.
Respir Res. 2023 Nov 7;24(1):272. doi: 10.1186/s12931-023-02590-4. Epub 2023 Nov 7
Razi N,Li W,Ignacio MA,Loube JM,Agostino EL,Zhu X,Scull MA,DeStefano JJ
Inhibition of SARS-CoV-2 Infection in Human Airway Epithelium with a Xeno-Nucleic Acid Aptamer.
bioRxiv. 2023 Sep 28;:. pii: 2023.09.27.559799. doi: 10.1101/2023.09.27.559799. Epub 2023 Sep 28
Song D,Iverson E,Kaler L,Boboltz A,Scull MA,Duncan GA
MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium.
Sci Adv. 2022 Nov 25;8(47):eabq5049. doi: 10.1126/sciadv.abq5049. Epub 2022 Nov 25
Iverson E,Griswold K,Song D,Gagliardi TB,Hamidzadeh K,Kesimer M,Sinha S,Perry M,Duncan GA,Scull MA
Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium.
mBio. 2022 Aug 30;13(4):e0105522. doi: 10.1128/mbio.01055-22. Epub 2022 Jun 14
Gagliardi TB,Iverson E,DeGrace EJ,Rosenberg BR,Scull MA
Immunofluorescence-Mediated Detection of Respiratory Virus Infections in Human Airway Epithelial Cultures.
Curr Protoc. 2022 Jun;2(6):e453. doi: 10.1002/cpz1.453. Epub
Goldstein ME,Scull MA
Modeling Innate Antiviral Immunity in Physiological Context.
J Mol Biol. 2022 Mar 30;434(6):167374. doi: 10.1016/j.jmb.2021.167374. Epub 2021 Dec 1
Kaler L,Iverson E,Bader S,Song D,Scull MA,Duncan GA
Influenza A virus diffusion through mucus gel networks.
Commun Biol. 2022 Mar 22;5(1):249. doi: 10.1038/s42003-022-03204-3. Epub 2022 Mar 22
Gagliardi TB,Goldstein ME,Song D,Gray KM,Jung JW,Ignacio MA,Stroka KM,Duncan GA,Scull MA
Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium.
PLoS Pathog. 2022 Jan;18(1):e1010159. doi: 10.1371/journal.ppat.1010159. Epub 2022 Jan 7
Song D,Iverson E,Kaler L,Bader S,Scull MA,Duncan GA
Modeling Airway Dysfunction in Asthma Using Synthetic Mucus Biomaterials.
ACS Biomater Sci Eng. 2021 Jun 14;7(6):2723-2733. doi: 10.1021/acsbiomaterials.0c01728. Epub 2021 Apr 19
Iverson E,Kaler L,Agostino EL,Song D,Duncan GA,Scull MA
Leveraging 3D Model Systems to Understand Viral Interactions with the Respiratory Mucosa.
Viruses. 2020 Dec 11;12(12):. doi: 10.3390/v12121425. Epub 2020 Dec 11
Yu Y,Scheel TKH,Luna JM,Chung H,Nishiuchi E,Scull MA,Echeverría N,Ricardo-Lax I,Kapoor A,Lipkin WI,Divers TJ,Antczak DF,Tennant BC,Rice CM
Correction: miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence.
PLoS Pathog. 2018 Sep;14(9):e1007303. doi: 10.1371/journal.ppat.1007303. Epub 2018 Sep 17
Andreo U,de Jong YP,Scull MA,Xiao JW,Vercauteren K,Quirk C,Mommersteeg MC,Bergaya S,Menon A,Fisher EA,Rice CM
Analysis of Hepatitis C Virus Particle Heterogeneity in Immunodeficient Human Liver Chimeric fah-/- Mice.
Cell Mol Gastroenterol Hepatol. 2017 Nov;4(3):405-417. doi: 10.1016/j.jcmgh.2017.07.002. Epub 2017 Jul 19
Yu Y,Scheel TKH,Luna JM,Chung H,Nishiuchi E,Scull MA,Echeverría N,Ricardo-Lax I,Kapoor A,Lipkin WI,Divers TJ,Antczak DF,Tennant BC,Rice CM
miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence.
PLoS Pathog. 2017 Oct;13(10):e1006694. doi: 10.1371/journal.ppat.1006694. Epub 2017 Oct 30
Hoffmann HH,Schneider WM,Blomen VA,Scull MA,Hovnanian A,Brummelkamp TR,Rice CM
Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.
Cell Host Microbe. 2017 Oct 11;22(4):460-470.e5. doi: 10.1016/j.chom.2017.09.002. Epub
Takacs CN,Andreo U,Dao Thi VL,Wu X,Gleason CE,Itano MS,Spitz-Becker GS,Belote RL,Hedin BR,Scull MA,Rice CM,Simon SM
Differential Regulation of Lipoprotein and Hepatitis C Virus Secretion by Rab1b.
Cell Rep. 2017 Oct 10;21(2):431-441. doi: 10.1016/j.celrep.2017.09.053. Epub