Brian Pierce

Kędzior M,Phulera S,Fernández-Quintero ML,Loeffler JR,Joyce C,Woehl J,Abbasi A,Karimi M,Aslanabadi A,Hojabri M,Zareidoodeji R,Atkinson B,Burgos EFP,Heredia A,Saye-Francisco K,Tran Q,Kim Y,Acosta-Puente F,Shahin L,Zhou A,Altman PX,Felbinger NR,Pierce BG,Sok D,Seaman MS,Burton DR,DeVico AL,Ward AB,Ozorowski G,Sajadi MM,Jardine JG

Engineering HIV antibodies with enhanced breadth and potency of neutralization through multistate affinity maturation.

bioRxiv. 2025 Oct 23;:. pii: 2025.10.22.684031. doi: 10.1101/2025.10.22.684031. Epub 2025 Oct 23

Tao Z,Thakare RP,Cheung M,Zhang J,Chen X,Hu X,Pierce BG,Wu X,Mao J

Dynamic S-acylation of GSDMA regulates pyroptosis.

bioRxiv. 2025 Oct 16;:. pii: 2025.10.16.682910. doi: 10.1101/2025.10.16.682910. Epub 2025 Oct 16

Laurenson AJ,Pierce BG,Takala-Harrison S,Laurens MB

Computational Prioritization of T Cell Epitopes to Overcome HLA Restriction and Antigenic Diversity in Plasmodium falciparum.

bioRxiv. 2025 Jul 18;:. pii: 2025.07.14.664425. doi: 10.1101/2025.07.14.664425. Epub 2025 Jul 18

Sajadi MM,Abbasi A,Tehrani ZR,Siska C,Clark R,Chi W,Seaman MS,Mielke D,Wagh K,Liu Q,Jumpa T,Ketchem RR,Nguyen DN,Tolbert WD,Pierce BG,Atkinson B,Deming D,Sprague M,Asakawa A,Ferrer D,Dunn Y,Calvillo S,Yin R,Guest JD,Korber B,Mayer BT,Sato AH,Ouyang X,Foulke S,Habibzadeh P,Karimi M,Aslanabadi A,Hojabri M,Saadat S,Zareidoodeji R,Kędzior M,Pozharski E,Heredia A,Chen H,Montefiori D,Ferrari G,Pazgier M,Lewis GK,Jardine JG,Lusso P,DeVico A

A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.

Structure. 2025 Jul 3;33(7):1150-1164.e8. doi: 10.1016/j.str.2025.04.016. Epub 2025 May 14

Sachdev S,Roy S,Saha SJ,Zhao G,Kumariya R,Creemer BA,Yin R,Pierce BG,Bewley CA,Cheloha RW

Evaluation of AlphaFold modeling for elucidation of nanobody-peptide epitope interactions.

J Biol Chem. 2025 Jul;301(7):110268. doi: 10.1016/j.jbc.2025.110268. Epub 2025 May 21

Shahid S,Karade SS,Hasan SS,Yin R,Jiang L,Liu Y,Felbinger N,Kulakova L,Toth EA,Keck ZY,Foung SKH,Fuerst TR,Pierce BG,Mariuzza RA

Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers.

Commun Biol. 2025 May 29;8(1):825. doi: 10.1038/s42003-025-08239-w. Epub 2025 May 29

Sachdev S,Roy S,Saha S,Zhao G,Kumariya R,Creemer BA,Yin R,Pierce BG,Bewley CA,Cheloha RW

Evaluation of Alphafold modeling for elucidation of nanobody-peptide epitope interactions.

bioRxiv. 2025 Mar 18;:. pii: 2025.03.14.643405. doi: 10.1101/2025.03.14.643405. Epub 2025 Mar 18

Lin S,Sallapalli BT,Chang P,He J,Coyaud E,Pierce BG,Zhang YJ

RNA Helicase DDX3 Interacts with the Capsid Protein of Hepatitis E Virus and Plays a Vital Role in the Viral Replication.

Pathogens. 2025 Feb 10;14(2):. doi: 10.3390/pathogens14020177. Epub 2025 Feb 10

Gowthaman R,Park M,Yin R,Guest JD,Pierce BG

AlphaFold and Docking Approaches for Antibody-Antigen and Other Targets: Insights From CAPRI Rounds 47-55.

Proteins. 2025 Jan 20;:. doi: 10.1002/prot.26801. Epub 2025 Jan 20

Lin V,Cheung M,Gowthaman R,Eisenberg M,Baker BM,Pierce BG

TCR3d 2.0: expanding the T cell receptor structure database with new structures, tools and interactions.

Nucleic Acids Res. 2025 Jan 6;53(D1):D604-D608. doi: 10.1093/nar/gkae840. Epub

Wu D,Yin R,Chen G,Ribeiro-Filho HV,Cheung M,Robbins PF,Mariuzza RA,Pierce BG

Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens.

Sci Adv. 2024 Nov 22;10(47):eadq6150. doi: 10.1126/sciadv.adq6150. Epub 2024 Nov 22

Sajadi MM,Abbasi A,Tehrani ZR,Siska C,Clark R,Chi W,Seaman MS,Mielke D,Wagh K,Liu Q,Jumpa T,Ketchem RR,Nguyen DN,Tolbert WD,Pierce BG,Atkinson B,Deming D,Sprague M,Asakawa A,Ferrer D,Dunn Y,Calvillo S,Yin R,Guest JD,Korber B,Mayer BT,Sato AH,Ouyang X,Foulke S,Habibzadeh P,Karimi M,Aslanabadi A,Hojabri M,Saadat S,Zareidoodeji R,Kędzior M,Pozharski E,Heredia A,Montefiori D,Ferrari G,Pazgier M,Lewis GK,Jardine JG,Lusso P,DeVico A

A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.

bioRxiv. 2024 Oct 17;:. pii: 2024.10.14.618178. doi: 10.1101/2024.10.14.618178. Epub 2024 Oct 17

Ribeiro-Filho HV,Jara GE,Guerra JVS,Cheung M,Felbinger NR,Pereira JGC,Pierce BG,Lopes-de-Oliveira PS

Exploring the potential of structure-based deep learning approaches for T cell receptor design.

PLoS Comput Biol. 2024 Sep;20(9):e1012489. doi: 10.1371/journal.pcbi.1012489. Epub 2024 Sep 30

Reinstein ZZ,Zhang Y,Ospina OE,Nichols MD,Chu VA,Pulido AM,Prieto K,Nguyen JV,Yin R,Moran Segura C,Usman A,Sell B,Ng S,de la Iglesia JV,Chandra S,Sosman JA,Cho RJ,Cheng JB,Ivanova E,Koralov SB,Slebos RJC,Chung CH,Khushalani NI,Messina JL,Sarnaik AA,Zager JS,Sondak VK,Vaske C,Kim S,Brohl AS,Mi X,Pierce BG,Wang X,Fridley BL,Tsai KY,Choi J

Preexisting Skin-Resident CD8 and γδ T-cell Circuits Mediate Immune Response in Merkel Cell Carcinoma and Predict Immunotherapy Efficacy.

Cancer Discov. 2024 Sep 4;14(9):1631-1652. doi: 10.1158/2159-8290.CD-23-0798. Epub

Felbinger N,Ribeiro-Filho HV,Pierce BG

Proscan: a structure-based proline design web server.

Nucleic Acids Res. 2024 Jul 5;52(W1):W280-W286. doi: 10.1093/nar/gkae408. Epub

Wu D,Yin R,Chen G,Ribeiro-Filho HV,Cheung M,Robbins PF,Mariuzza RA,Pierce BG

Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens.

bioRxiv. 2024 May 23;:. pii: 2024.05.21.595215. doi: 10.1101/2024.05.21.595215. Epub 2024 May 23

Pierce BG,Felbinger N,Metcalf M,Toth EA,Ofek G,Fuerst TR

Hepatitis C Virus E1E2 Structure, Diversity, and Implications for Vaccine Development.

Viruses. 2024 May 18;16(5):. doi: 10.3390/v16050803. Epub 2024 May 18

Ribeiro-Filho HV,Jara GE,Guerra JVS,Cheung M,Felbinger NR,Pereira JGC,Pierce BG,Lopes-de-Oliveira PS