Graduate program affiliations

  • BISI - BISI-Molecular & Cellular Biology (MOCB)

research interests

We are focusing on signal transduction of the plant hormone ethylene (C2H4), a simple gas that has profound effects on plant growth and development. Our research utilizes a combination of molecular biology, genetics, cell biology and proteomics in order to understand the molecular mechanisms of ethylene signaling. Our model system is the small flowering plant Arabidopsis thaliana.


recent publications

Chang C. (2016) How do plants respond to ethylene and why is this important? BMC Biology 14: 7  doi:10.1186/s12915-016-0230-0


Ju C., Van de Poel B., Cooper E.D., Thierer J.H., Gibbons T.R., Delwiche C.F. and Chang C. (2015) Conservation of ethylene as a plant hormone over 450 million years of evolution. Nature Plants 1: Article 14004. doi: 10.1038/nplants.2014.4


Ju C. and Chang C. (2015) Mechanistic insights in ethylene perception and signal transduction. Plant Physiol. 169: 85-95.


Chang J., Clay J.M. and Chang C. (2014) Association of cytochrome b5  with ETR1 ethylene receptor signaling through RTE1 in Arabidopsis. 
Plant J. 77 558-567.


Ju C.,Yoon G., Shemansky J., Lin D., Ying Z.I., Chang J., Garrett, W. Kessenbrock M., Groth G., Tucker M.L., Cooper B., Kieber J.J., and Chang C. (2012) CTR1 phosphorylates EIN2 to control ethylene signaling from the ER membrane to the nucleus. Proc. Natl. Acad. Sci. USA 109: 19486-19491 doi:10.1073/pnas.1214848109


Chen R., Binder B., Garrett W.M., Tucker M.L., Chang C. and Cooper B. (2011) Proteomic responses in Arabidopsis thaliana seedlings treated with ethylene. Mol. Biosys. 7:2637-2650.


Dong CH, Jang M, Scharein B, Malach A, Rivarola M, Liesch J, Groth G, Hwang I and Chang C. (2010) Molecular association of the Arabidopsis ETR1 ethylene receptor and a regulator of ethylene signaling, RTE1. J Bio. Chem. 52: 40706-40713 [full text]


Rivarola M., McClellan C.A., Resnick J.S. and Chang C. (2009) ETR1-specific mutations distinguish ETR1 from other Arabidopsis ethylene receptors as revealed by genetic interaction with RTE1Plant Physiol. 150: 547-551 [full text]


Resnick J.S., Rivarola M. and Chang C. (2008) Involvement of RTE1 in conformational changes promoting ETR1 ethylene receptor signaling in Arabidopsis. Plant J. 56: 423-431 [full text]


Gao Z., Wen C.-K., Binder B.M., Chen Y.-F, Chang J., Chiang Y.-H., Kerris R.J. III, Chang C. and Schaller G.E. (2008) Heteromeric interactions among ethylene receptors mediate signaling in Arabidopsis. J. Biol. Chem. 283: 23801-23810 [full text]


Kendrick M.D. and Chang C. (2008) Ethylene signaling: new levels of complexity and regulation. Curr. Opin. Plant Biol. 11: 479-485 [full text]


McClellan C.M. and Chang C. (2008) The role of protein turnover in ethylene biosynthesis and response. Plant Science 174: 24-31. [full text]


Dong C.-H., Rivarola M., Resnick J.S., Maggin B.D. and Chang C. (2008) Subcellular co-localization of Arabidopsis RTE1 and ETR1 supports a regulatory role for RTE1 in ETR1 ethylene signaling. Plant J. Jan;53(2):275-86. Epub 2007 Nov 12. [full text]


Resnick J.S. and Chang C. (2007) Ethylene. In: Encyclopedia of Life Sciences (John Wiley & Sons, Ltd, Chichester)[doi:10.1002/9780470015902.a0020099].


Wang W., Esch J.J., Shiu S., Agula H., Binder B.M., Chang C., Patterson, S.E. and Bleecker A.B. (2006) Identification of important regions for ethylene binding and signaling in the transmembrane domain of the ETR1 ethylene receptor of Arabidopsis Plant Cell 18: 3429- 3442. [full text ]


Resnick J.S., Wen C.-K., Shockey J.A. and Chang C. (2006) REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor function in ArabidopsisProc. Natl. Acad. Sci. USA 103: 7917-7922. [full text]



Ph.D. Caltech 1988