Antony M Jose

Associate Professor

 

Contact

Emailamjose@umd.edu

Office Phone: (301)405.7028

Lab Phone: (301)405.9513

Lab: 2205 Bioscience Research Building

Office Address: 2136 Bioscience Research Building

URL: http://www.clfs.umd.edu/cbmg/joselab/

 


graduate program affiliations

  • BISI - BISI-Molecular & Cellular Biology (MOCB)

research interests

Life relies on regulation from molecular to population scales. We are interested in advancing the understanding of living systems through conceptual and experimental work on regulation. Conceptually, we aim to explore the origins, diversity, and limits of regulatory architectures. Experimentally, we aim to elucidate mechanisms that use RNA to regulate gene expression across space and time using the nematode Caenorhabditis elegans.

 

Please visit our website for more.

 

recent publications

 

Preprints

Galford KF, Jose AM. (2020) The FDA-approved drugs ticlopidine, sertaconazole, and dexlansoprazole can cause morphological changes in C. elegans. bioRxiv: 10.1101/2020.04.09.034421v1 (Online on 4/11/2020).

 

Devanapally* S, Raman* P, Allgood S, Ettefa F, Diop M, Chey M, Lin Y, Cho YE, Yin R,  Jose AM. (2020) Recovery from transgenerational RNA silencing is driven by gene-specific homeostasis. bioRxiv: 10.1101/148700v3 (Online on 1/7/2020). *equal contribution.

 

Published

 

2020:

Jose AM. A framework for parsing heritable information. J. R. Soc. Interface. 17:20200154. (Online on 3/20/2020, arXiv).

 

Jose AM. Heritable epigenetic changes alter transgenerational waveforms maintained by cycling stores of information. BioEssays. 201900254.

 

2019:

Ravikumar S, Devanapally S, Jose AM. Gene silencing by double-stranded RNA from C. elegans neurons reveals functional mosaicism of RNA interference. Nucleic Acids Research. 47(19):10059-71.

 

2018:

Jose AM. Replicating and cycling stores of information perpetuate life. BioEssays. 40(4):1700161. 

 

2017: 

Raman P, Zaghab S, Traver EC, Jose AM. The double-stranded RNA binding protein RDE-4 can act cell autonomously during feeding RNAi in C. elegans. Nucleic Acids Research. 45(14):8463-73.

 

Choi YS, Edwards LO, DiBello A, Jose AM. Removing bias against short sequences enables northern blotting to better complement RNA-seq for the study of small RNAs. Nucleic Acids Research. 45(10):e87.

 

Marré J, Jose A. Inheritance of extracellular nutrition and information in Caenorhabditis elegans. Molecular Reproduction & Development. 84(4):283.

 

2016:

Marré JA, Traver EC, Jose AM. Extracellular RNA is transported from one generation to the next in C. elegans. Proceedings of the National Academy of Sciences USA. 113(44):12496-501.

 

Le HH, Strauss B, Bloodgood M, Jose AM. Tissue homogeneity requires inhibition of unequal gene silencing during development. Journal of Cell Biology. 214(3): 319-331.

 

Blumenfeld AL, Jose AM. Reproducible features of small RNAs in C. elegans reveal NU RNAs and provide insights into 22G RNAs and 26G RNAs. RNA. 22:184-192.

 

2015:

Jose AM. Movement of regulatory RNA between animal cells. genesis. 53(7): 395-416.

 

Devanapally S, Ravikumar S, Jose AM. Double-stranded RNA made in C. elegans neurons can enter the germline and cause transgenerational gene silencing. Proceedings of the National Academy of Sciences USA. 112(7):2133-8.

 

 

 

awards

2019               Graduate Faculty Mentor of the Year, UMD

 

2016               National Academy of Sciences Kavli Fellow

 

education

2005               PhD, Yale University

 

2011               Postdoc, Harvard University