Life relies on regulation from molecular to population scales. We are interested in advancing the understanding of living systems through conceptual and experimental work on regulation. Conceptually, we aim to explore the origins, diversity, and limits of regulatory architectures. Experimentally, we aim to elucidate mechanisms that use RNA to regulate gene expression across space and time using the nematode Caenorhabditis elegans.
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Shugarts N, Yi AL, Chan WM, Marré JA, Sathya A, Jose AM. Intercellular transport of RNA can limit heritable epigenetic changes. bioRxiv. (Online Oct 6, 2021).
Chey M, Jose AM. Heritable epigenetic changes at single genes: challenges and opportunities in Caenorhabditis elegans. Trends in Genetics. 38(2):116-119.
Devanapally S*, Raman P*, Chey M, Allgood S, Ettefa F, Diop M, Lin Y, Cho YE, Jose AM. Mating can initiate stable RNA silencing that overcomes epigenetic recovery. Nature Communications 12:4239. (Online Jan 7, 2020, BioRxiv). *equal contribution
Galford KF, Jose AM. The FDA-approved drugs ticlopidine, sertaconazole, and dexlansoprazole can cause morphological changes in C. elegans. Chemosphere 261:127756. (Online Apr 11, 2020, bioRxiv).
Jose AM. The analysis of living systems can generate both knowledge and illusions. eLife 9:e56354.
Jose AM. A framework for parsing heritable information. J. R. Soc. Interface. 17:20200154. (Online on 3/20/2020, arXiv).
Jose AM. Heritable epigenetic changes alter transgenerational waveforms maintained by cycling stores of information. BioEssays. 201900254.
Ravikumar S, Devanapally S, Jose AM. Gene silencing by double-stranded RNA from C. elegans neurons reveals functional mosaicism of RNA interference. Nucleic Acids Research. 47(19):10059-71.
Jose AM. Replicating and cycling stores of information perpetuate life. BioEssays. 40(4):1700161.
Raman P, Zaghab S, Traver EC, Jose AM. The double-stranded RNA binding protein RDE-4 can act cell autonomously during feeding RNAi in C. elegans. Nucleic Acids Research. 45(14):8463-73.
Choi YS, Edwards LO, DiBello A, Jose AM. Removing bias against short sequences enables northern blotting to better complement RNA-seq for the study of small RNAs. Nucleic Acids Research. 45(10):e87.
Marré J, Jose A. Inheritance of extracellular nutrition and information in Caenorhabditis elegans. Molecular Reproduction & Development. 84(4):283.
Marré JA, Traver EC, Jose AM. Extracellular RNA is transported from one generation to the next in C. elegans. Proceedings of the National Academy of Sciences USA. 113(44):12496-501.
Le HH, Strauss B, Bloodgood M, Jose AM. Tissue homogeneity requires inhibition of unequal gene silencing during development. Journal of Cell Biology. 214(3): 319-331.
Blumenfeld AL, Jose AM. Reproducible features of small RNAs in C. elegans reveal NU RNAs and provide insights into 22G RNAs and 26G RNAs. RNA. 22:184-192.
Jose AM. Movement of regulatory RNA between animal cells. genesis. 53(7): 395-416.
Devanapally S, Ravikumar S, Jose AM. Double-stranded RNA made in C. elegans neurons can enter the germline and cause transgenerational gene silencing. Proceedings of the National Academy of Sciences USA. 112(7):2133-8.
2019 Graduate Faculty Mentor of the Year, UMD
2016 National Academy of Sciences Kavli Fellow
2005 PhD, Yale University
2011 Postdoc, Harvard University