Wenxia Song





Office Phone: (301) 405-7552

Fax: (301) 314-9489

Office Address: 2104 Bioscience Research Building

Lab Address: 2217 Bioscience Research Building





Immunology Laboratory



Advanced Cell Biology

graduate program affiliations

  • BISI - BISI-Molecular & Cellular Biology (MOCB)

research interests

Cellular and Molecular Immunology.


recent publications


Qin, T., Y. An, C. Liu, J. Wu, R. Dai, D. Liu, X. Li, L. Jiang, D. Wu, X. Tang, W. Song, T. Wang, and X. Zhao. 2016. Novel DOCK8 gene mutations lead to absence of protein expression in patients with hyper-IgE syndrome. Immunol. Res. 64(1):260-71.


Miller, H., T. Castro-Gomes, M. Corrotte, C. Tam, T. K. Maugel, N. W. Andrews, and W. Song#. 2015. Lipid raft-dependent plasma membrane repair interferes with the activation of B-lymphocytes. J. Cell Biol. 211(6):1193-205. Highlighted In This Issue.


Stein, D. C., A. LeVan, B. Hardy, L-C. Wang, L. Zimmerman, and W. Song#. 2015. Expression of opacity protein interferes with the transmigration of Neisseria gonorrhoeae across polarized epithelial cells. PLoS One. 10(8):e0134342.


Palaniyand, S., X. Liu, S. Periasamy, A. Ma, J. Tang, M. Jenkins, W. Tuo, W. Song, A. D. Keegan, D. H. Conrad, and X. Zhu. 2015. Inhibition of CD23-medited IgE transcytosis suppresses the initiation and development of allergic airway inflammation. Mucosal Immunol. 8(6):1262-74.


Wu, J., D. Liu, W. Tu, W. Song, and X. Zhao. 2015. T-cell receptor diversity is selectively skewed in T-cell populations of patients with Wiskott-Aldrich syndrome. J. Allergy Clin. Immunol. 135(1):209-16.


Seeley-Fallen, M. K., L. J. Liu, M. R. Shapiro, O. O. Onabajo, T-H Tan, A. Upadhyaya, and W. Song#. 2014. Actin binding protein-1 links B-cell receptor to negative signaling pathways. Proc. Natl. Acad. Sci. USA. 111:9881-9886.


Miao H., J. Ou, Y. Ma, F. Guo, Z. Yang, M. Wiggins, C. Liu, W. Song. Han, M. Wang, Q. Cao, B. H. Chung, D. Yang, H. Liang, B. Xue, H. Shi, L. Gan, and L. Yu. Macrophage CGI-58 deficiency activates ROS-inflammasome pathway to promote insulin resistance in mice. Cell Rep. 2014. 10;7(1):223-35.


Ketchum, C., Miller H., Song W., and Upadhyaya A. 2014. Ligand mobility regulates B cell receptor clustering and signaling activation. Biophys. J. 106(1):26-36.


Liu, C., X. Bai, J. Wu, S. Sharma, A. Upadhyaya, C. I. M. Dahlberg, L. S. Westerberg, S. B. Snapper, X. Zhao, and W. Song#. 2013. N-WASP is essential for the negative regulation of B cell receptor signaling. PLOS Biol. 11(11): e1001704.


Song, W.#, C. Liu, M. K. Seeley-Fallen, H. Miller, C. Ketchum, and A. Upadhyaya. 2013. Actin-mediated feedback loops in B-cell receptor signaling. Immunol. Rev. 256(1):177-189.


Liu, C., M. K. Fallen, H. Miller, A. Upadhyaya, and Song, W#. 2013. The actin cytoskeleton coordinates the signal transduction and antigen processing functions of the B cell antigen receptor. Front. Biol. 8(5):475-485.


Corrotte, M., P. E. Almeida, C. Tam, T. Gastro-Gomes, M. C. Fernandes, B. A. Millis, M. Cortez, H. Miller, W. Song, T. K. Maugel, and N. W. Andrews. 2013. Caveolea internalization repairs wounded cells and muscle fibers. Elife 2:e00926.


Arunkumar, N., C. Liu, H. Hang and W. Song#. 2013. Toll-like receptor agonists induce apoptosis in mouse B-cell lymphoma cells by altering NF-B activation. Cell. Mol. Immunol. 10(4):360-72.


Song, W.#, C. Liu, and A. Upadhyaya. 2013. The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation. Biochim. Biophys. Act. S0005-2736(13):00256-3.


Edwards, V. L., L. C. Wang, V. Dawson, D. C. Stein, and W. Song#. 2013. Neisseria gonorrhoeae breaches the apical junction of polarized epithelial cells for transmigration by activating EGFR. Cell. Microb. 15(6):1042-57.


Liu, C., H. Miller, S. Sharma, A. Beaven, A. Upadhyaya, and W. Song#. 2012. Analyzing actin dynamics during the activation of the B cell receptor in live B cells. Biochem. Biophys. Res. Commun. 427(1):202-6.


Levan, A., L. I. Zimmerman, A. C. Mahle, K. V. Swanson, P. Deshong, J. Park, V. L. Edwards, W. Song, and D. C. Stein. 2012. Construction and Charaterization of a derivative of Neisseria gonorrhoeae strain MS11 devoid of all opa genes. J. Bacteriol. 194(23):6468-78.


Liu, C., H. Miller, G. Orlowski, H. Hang, A. Upadhyaya, and W. Song#. 2012. Actin reorganization is required for the formation of polarized BCR signalosomes in response to both soluble and membrane-associated antigens. J. Immunol. 188(7):3237-46.


Subramanian, S., K. H. Aschenbach, J. P. Evangelista, M. B. Najjar, W. Song, and R. D. Gomez. 2012. Rapid, sensitive and label-free detection of Shiga-toxin producing Escherichia coli O157 using carbon nanotube biosensors. Biosens. Bioelectron. 32(1):69-75.


Becker-Herman, S., A. Meyer-Bahlburg, M. A. Schwartz, S. W. Jackson, K. L. Hudkins, C. Liu, B. D. Sather, S. Khim, D. Liggitt, W. Song, G. J. Silvermann, C. E. Alpers and D. J. Rawlings. 2011. WASp deficient B cells play a critical, cell intrinsic role in triggering autoimmunity. J. Exp. Med. 208(10):2033-42.


Swanson, K. B., J. M. Griffiss, V. L. Edwards, D. C. Stein and W. Song#. 2011. Neisseria gonorrhoeae-induced transactivation of EGFR is required for gonococcal invasion. Cell. Microl. 13(7), 1078-1090.


Liu, C., H. Miller, G. Orlowsky, S. Sharma, H-K Lam, B. Grooman, S. Bolland, A. Upadhyaya, and W. Song#. 2011. A balance between Btk and SHIP-1 activation regulate B cell receptor clustering via modulating actin remodeling. J. Immunol. 187(1):230-9.


Sharma, S., G. Orlowski and W. Song#. 2009. Btk regulates BCR-mediated antigen processing and presentation by controlling the actin cytoskeleton dynamics in B cells. J. Immunol. 182: 329–339.


Song W#., S. Condron, B. T. Mocca, S. J. Veit, D. Hill, A. Abbas, and A. E. Jerse. 2008. Local and Humoral Immune Responses against Primary and Repeat Neisseria gonorrhoeae Genital Tract Infections of 17-β Estradiol-treated Mice. Vaccine. 26(45):5741-51.


Bish S. E., W. Song, and D. C. Stein. 2008. Quantification of bacterial invasion into host cells using a -lactamase reporter strain: Neisseria gonorrhoeae invasion into cervical epithelial cells requires bacterial viability. Microb. Infect. 10(10-11):1182-91.


Ye L., X. Liu, S. N. Rout, Y. Yan, S. K. Samal, W. Song and X. Zhu. 2008. The MHC class II-associated invariant chain interacts with Fc receptor FcRn and modulates its trafficking to endosomal/lysosmal comparatment. J. Immunol. 181(4):2572-85.


Zheng, J., J. Meng, S. Zhao, R. Singh, and W. Song#. 2008. Campylobacter-induced interleukin 8 in human intestinal epithelia cells required Campylobacter-secreted CDT and TLR-mediated activation of NF-B. Infect. Immun. 76(10):4498-508.


Onabajo, O., M. Seeley, A. Kale, B. Qualmann, M. Kessels, S-H. Tan, and W. Song. 2008. Mammalian actin-binding protein 1 regulates BCR-mediated antigen processing and presentation in response to BCR activation. J. Immunol. 180(10):6685-95.




Ph.D. Kansas State University, 1991