• BISI - BISI-Molecular & Cellular Biology (MOCB)
• Physiological Systems (PSYS)

Cell-cell communication is the bandmaster that orchestrates an amazing transformation of a single-cell zygote into many different types of cells and organizes them into intricate patterns within the emerging body plan in a developing embryo. Our laboratory aims to understand how cells in multicellular organisms communicate with morphogenetic signals to coordinate in space and time and organize themselves to generate complex tissue architectures. Read more.
ResearchGate Lab page: https://www.researchgate.net/lab/Sougata-Roy-Lab

Funding 

NIH/NIGMS

NIH/NHLBI 

Recent lab news and recognitions: https://sougatalabumd.wixsite.com/roylab/news

2019

Drosophila FGF cleavage is required for efficient intracellular sorting and intercellular dispersal. Sohr A, Du L, Wang R, Lin L, Roy S. J Cell Biol. 2019. pii: jcb.201810138. doi: 10.1083/jcb.201810138. PubMed PMID: 30808704.

Ex vivo Drosophila Wing Imaginal Disc Culture and Furin Inhibitor Assay. Sohr A, Du L, Roy S. Bio-protocol. Vol 9, Iss 16, August 20, 2019.  DOI:   10.21769/BioProtoc.3336. 

2018

Feedback regulation of cytoneme-mediated transport shapes a tissue-specific FGF morphogen gradient. Du L, Sohr A, Yan G, Roy S. Elife. 2018. doi: 10.7554/eLife.38137.

An efficient strategy for generating tissue-specific binary transcription systems in Drosophila by Genome Editing. Du L, Zhou A, Sohr A, Roy S. J Vis Exp. 2018. doi: 10.3791/58268.

Imaging cytonemes in Drosophila embryos. Du L, Roy S. Book chapter In: Morphogen Gradients, Methods in Molecular Biology, vol 1863. Humana Press, New York, NY; 2018.1863:29-45. doi: 10.1007/978-1-4939-8772-6_3. Erratum in: Methods Mol Biol. 2018;1863:E1.

2017

Unique patterns of organization and migration of FGF-expressing cells during Drosophila morphogenesis. Du L, Zhou A, Patel A, Rao M, Anderson K, Roy S. Dev Biol. 2017 Jul 1; 427(1):35-48. doi: 10.1016/j.ydbio.2017.05.009.

2015

Roy S,* and Kornberg T.B. Paracrine signaling mediated at cell-cell contacts. BioEssays 2015. 37(1): 25–33. (*, corresponding author; published online: 5 DEC 2014, DOI: 10.1002/bies.201400122). Video abstract: https://youtu.be/YTz_0hM1gWE

Rao PR, Lin L, Huang H, Guha A, Roy S, Kornberg TB. Developmental compartments in the larval trachea of Drosophila. Elife. 2015 Oct 22;4. pii: e08666. doi: 10.7554/eLife.08666. PMID: 26491942    

2014

Roy S, Huang H, Liu S and Kornberg TB. Cytoneme-mediated contact-dependent transport of the Drosophila Decapentaplegic signaling protein. Science, 2014. 343(6173):852, 1244624/

Kornberg TB, Roy S. Cytonemes as specialized signaling filopodia. Development, 2014. 141:729-736.

Kornberg TB, Roy S. Communicating by touch – neurons are not alone. Trends in Cell Biology, 2014. 24(6): 370-376 (Published online on 21st February, 2014; 10.1016/j.tcb.2014.01.003).

2011

Roy S, Hsiung F, Kornberg TB. Specificity of Drosophila cytonemes for distinct signaling pathways.Science. 2011; 332(6027):354-8.

Roy S, Kornberg TB. Direct delivery mechanisms of morphogen dispersion. Science Signaling. 2011 22; 4 (200):pt8. 

Complete list of published work

Check: my bibliography; Google Scholar; and ORCID iD: 0000-0002-2236-9277 

Ph.D. 2006. Indian Institute of Science, Bangalore, India.

Post-doctoral fellowship (2006-2014). Department of Biochemistry and Cardiovascular Research Institute, University of California, San Francisco.