• BISI - BISI-Molecular & Cellular Biology (MOCB)

Macrophages and dendritic cells occupy a unique niche in the immune system. These cells can participate in host defense to infectious microorganisms, and promote host inflammatory responses. They can also mitigate inflammatory responses and down regulate adaptive immunity. A variety of approaches in Immunology and Cell Biology are being taken to understand the molecular mechanisms by which these fascinating cells can mediate these divergent processes.

Studies on host defense to infectious diseases focus on: I) the cell and molecular biology of macrophage infection by intracellular pathogens. II) the molecules produced by macrophages that mediate the killing of intracellular pathogens. III) an analysis of monocyte or macrophage subsets during infectious diseases.

Studies relating to the host inflammatory response focus on: I) the regulation of cytokine gene expression in macrophages and dendritic cells. II) receptor-mediated modulation of cytokine production by regulatory macrophages. III) the development of novel anti-inflammatory therapeutics to treat autoimmune diseases.

Zhang, X. and Mosser, D.M.  2008.  Macrophage activation by endogenous danger signals.  J. Pathol. 214:161-78.

Bonfield, T.L., Thomassen, M.J., Farver, C.F., Abraham, S. Koloze, M.T., Zhang, X., Mosser, D.M. and Culver, D.A. 2008.  J. Immunology 181:235-42.

Zhang, X. Goncalves, R. and Mosser, D.M. 2008. The isolation and characterization of murine macrophages. Current Protocols Immunology. Unit 14.1

Mosser, D.M. and Zhang, X. 2008. Activation of murine macrophages.  Current Protocols Immunology. Unit 14.2

Mosser, D.M. and Zhang, X. 2008.  IL-10: New perspectives on an old cytokine.  Immunological Reviews. 226:205-218

Mosser, D.M. and Edwards, J. P. 2008.  Exploring the full spectrum of macrophage activation.  Nature Reviews Immunology. 8:958-969.

Marbach-Ad, G. Briken, V., El-Sayed, N., Frauwirth, K. Fredericksen, B., Hutcheson, S., Gao, L., Joseph, S., Lee, V., McIver, K. S., Mosser, D. M., Quimby, B. B., Shields, P. Song, W. Stein, D. C., Yuan, R. T. and Smith, A. C.  2009. Assessing Student Understanding of Host Pathogen Interactions Using a Concept Inventory. J. Microbiol. Biol. Edu. 10:43-50.

Cates, E.A., Connor, E.E., Mosser, D.M. and Bannerman, D.D. 2009.  Functional characterization of bovine TIRAP and MyD88 in mediating bacterial lipopolysaccharide-induced endothelial NF-kB activation and apoptosis. Comp. Immunol. Microbiol. Infect. Dis. 32:477-90.

Edwards, J.P. Zhang, X. and Mosser, D.M. 2009.  The expression of heparin-binding epidermal growth factor-like growth factor by regulatory macrophages.  J. Immunology 182:1929-39.

Zhang, X. Edwards, J.P. and Mosser, D.M. 2009. The expression of exogenous genes in macrophages: obstacles and opportunities. Methods in Mol. Biol.  531:123-43.

Gallo, P. Goncalves, R. and Mosser, D.M. 2010.  The influence of IgG Density on Phagocytosis and IL-10 Production following Macrophage Fc (gamma) Receptor Cross-linking.  Immunol Letters 133:70-7.

Halstead, S.A. Mahalingham, S. Marovich, M. A. Ubol, S. and Mosser, D.M.  2010.  Intrinsic antibody enhancement of infection in macrophages: disease regulation by immune complexes.  Lancet Infect. Dis. 10:712-22.

Marbach-Ad G. McAdams, K.C. Benson, S. Briken, V. Cathcart, L. Chase, M. El-Sayed, N. Frauwirth, K. Fredericksen, B. Joseph, S. Lee, V. McIver, K. Mosser, D.M. Quimby, B.B. Shields, P. Song, W. Stein, D.C. Stewart, R. Thompson, K.V. Smith, A.C. 2010. A model for using a concept inventory as a tool for students’ assessment and faculty professional development. CBE Life Sci Educ. 9:408-16.

Reis M.L. Ferreira, V.M. Zhang, X. Goncalves, R. Vieira L.Q. Tafuri, W.L. Mosser, D.M. and Tafuri, W.L. 2010. Murine immune responses induced by Leishmania major during the implantation of paraffin tablets.  Virchows Arch. 457:609-18.

Yang, Z. Zhang, X. Darrah, P.A. and Mosser, D.M. 2010. The regulation of Th1 responses by the p38 MAPK. J. Immunol. 185:6205-13.

Liu, X. Lu, L. Yang, Z. Palaniyandi, S. Zeng, R. Gao, L.Y. Mosser, D.M. Roopenian, D.C. and Zhu, X. 2011.  The neonatal FcR mediated presentation of immune complexed antigen in associated with endosomal and phagosomal pH and antigan stability in macrophages and dendritic cells.  J. Immunol. 186:4674-86.

Yang, Z. Kong, B. Mosser, D.M. and Zhang, X. 2011.  TLRs, macrophages and NK cells: Our understanding of their function in the uterous and ovary. Int. Immunopharmacol. 11:1442-50.

Goncalves, R. Zhang, X. Cohen, H. Debrabant, A. and Mosser, D.M. 2011.  Platelet activation attracts a subpopulation of effector monocytes to sites of L. major infection.  J. Exp. Med. 208:1253-65.

Fleming,B.D. and Mosser, D.M. 2011 Regulatory macrophages:  Setting the threshold for therapy.  Eur. J. Immunol.  41:2498-502.

Briken, V. and Mosser, D.M. 2011.  Switching on arginase in M2 macrophages.  J. Leuk. Biol. 90:839-41.

Mosser, D.M. and Zhang, X.  2011. Measuring opsonic phagocytosis via Fcγ receptors and complement receptors on macrophages.  Curr. Protoc. Immunol. XChapter 14, Unit 14.27 

Liu, X. Lu, L. Yang, Z. Palaniyandi, S. Zeng, R. Gao, L.Y. Mosser, D.M. Roopenian, D.C. and Zhu, X. 2011.  The neonatal FcR mediated presentation of immune complexed antigen is associated with endosomal and phagosomal pH and antigan stability in macrophages and dendritic cells.  J. Immunol. 186:4674-86. 

Yang, Z. Kong, B. Mosser, D.M. and Zhang, X. 2011.  TLRs, macrophages and NK cells: Our understanding of their function in the uterous and ovary. Int. Immunopharmacol. 11:1442-50.

Goncalves, R. Zhang, X. Cohen, H.B. Debrabant, A. and Mosser, D.M. 2011.  Platelet activation attracts a subpopulation of  effector monocytes to sites of L. major infection.  J. Exp. Med. 208:1253-65.

Fleming, B.D. and Mosser, D.M. 2011. Regulatory macrophages:  Setting the threshold for therapy.  Eur. J. Immunol.   41:2498-502.

Briken, V. and Mosser, D.M.  2011.  Switching on arginase in M2 macrophages.  J. Leuk. Biol. 90:839-41.

Mosser, D.M. and Zhang, X.  2011. Measuring opsonic phagocytosis via Fcγ receptors and complement receptors on macrophages.  Curr. Protoc. Immunol. XChapter 14, Unit 14.27

Cohen, H.B. Briggs, K.T. Marino, J.P. Ravid, K. Robson, S.C. and Mosser, D.M. 2013. TLR stimulation initiates a CD39- based autoregulatory mechanism that limits macrophage inflammatory responses.  Blood 122:1935-45.

Cohen, H.B. and Mosser, D.M.  2013.  Extrinsic and intrinsic control of macrophage inflammatory responses.  J. Leuk. Biol. 94:913-9.

Suresh, R. and Mosser, D.M. 2013. Pattern recognition receptors in innate immunity, host defense, and immunopathology. Adv. Physiol. Educ. 37: 284-91.

Sousa, L.M. Carneiro, M.B. Resende, M.E. Mello, P.S. Martins, L.S. Dos Santos, L.M. Mosser, D.M. Oliveira, M.A. and Viera,  L.Q. 2014. Neutrophils have a protective role during early stages of Leishmania amazonensis infection in BALB/c mice. Parasite Immunol. 36:13-31.  

Cohen, H.B. and Mosser, D.M. 2014. Cardiac Macrophages: How to Mend a Broken Heart, Immunity  40:3-4.

Ph.D. in Immunology from North Carolina State University, 1983

Postdoctoral fellowship in Cell Biology at Harvard Medical School, 1985

Assistant Professor in Pediatrics at Cornell University Medical College, 1988

Associate, and Full Professor in Microbiology and Immunology at Temple University Medical School, 2000

Professor in CBMG and Director of the Maryland Pathogen Research Institute at University of Maryland, College Park, MD: present