Kan Cao headshot
Contact Info
Office: 2114 Bioscience Research Bldg
Phone: 301-405-3016
Cao Lab
Kan Cao
Professor
Associate Chair

Graduate Program Affiliations

  • BISI-Molecular & Cellular Biology (MOCB)  

Research Interests

Hutchinson Gilford progeria, telomere and cellular senescence, alternative splicing and human aging

Education

  • Ph.D., Johns Hopkins University, 2005

All Publications

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Latest Publications

Yu R,Xue H,Lin W,Collins FS,Mount SM,Cao K
Progerin mRNA expression in non-HGPS patients is correlated with widespread shifts in transcript isoforms.
NAR Genom Bioinform. 2024 Sep;6(3):lqae115. doi: 10.1093/nargab/lqae115. Epub 2024 Aug 29
Xue H,Gate S 3rd,Gentry E,Losert W,Cao K
Development of an accelerated cellular model for early changes in Alzheimer's disease.
Sci Rep. 2023 Oct 26;13(1):18384. doi: 10.1038/s41598-023-45826-5. Epub 2023 Oct 26
Abutaleb NO,Atchison L,Choi L,Bedapudi A,Shores K,Gete Y,Cao K,Truskey GA
Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome.
Sci Rep. 2023 Mar 28;13(1):5032. doi: 10.1038/s41598-023-32035-3. Epub 2023 Mar 28
Xue H,Cao K
Missing checkpoints in premature aging.
Nat Aging. 2023 Feb;3(2):146-147. doi: 10.1038/s43587-022-00351-4. Epub
Mao X,Xiong ZM,Xue H,Brown MA,Gete YG,Yu R,Sun L,Cao K
Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome.
Int J Mol Sci. 2022 May 14;23(10):. doi: 10.3390/ijms23105499. Epub 2022 May 14
Xue H,Thaivalappil A,Cao K
The Potentials of Methylene Blue as an Anti-Aging Drug.
Cells. 2021 Dec 1;10(12):. doi: 10.3390/cells10123379. Epub 2021 Dec 1
Fields E,Vaughan E,Tripu D,Lim I,Shrout K,Conway J,Salib N,Lee Y,Dhamsania A,Jacobsen M,Woo A,Xue H,Cao K
Gene targeting techniques for Huntington's disease.
Ageing Res Rev. 2021 Sep;70:101385. doi: 10.1016/j.arr.2021.101385. Epub 2021 Jun 5
Gete YG,Koblan LW,Mao X,Trappio M,Mahadik B,Fisher JP,Liu DR,Cao K
Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS.
Aging Cell. 2021 Jul;20(7):e13388. doi: 10.1111/acel.13388. Epub 2021 Jun 4
Xiong ZM,Mao X,Trappio M,Arya C,Kordi JE,Cao K
Ultraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health.
Sci Rep. 2021 May 28;11(1):10871. doi: 10.1038/s41598-021-89970-2. Epub 2021 May 28
Erdos MR,Cabral WA,Tavarez UL,Cao K,Gvozdenovic-Jeremic J,Narisu N,Zerfas PM,Crumley S,Boku Y,Hanson G,Mourich DV,Kole R,Eckhaus MA,Gordon LB,Collins FS
A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome.
Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038/s41591-021-01274-0. Epub 2021 Mar 11
Koblan LW,Erdos MR,Wilson C,Cabral WA,Levy JM,Xiong ZM,Tavarez UL,Davison LM,Gete YG,Mao X,Newby GA,Doherty SP,Narisu N,Sheng Q,Krilow C,Lin CY,Gordon LB,Cao K,Collins FS,Brown JD,Liu DR
In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.
Nature. 2021 Jan;589(7843):608-614. doi: 10.1038/s41586-020-03086-7. Epub 2021 Jan 6
Mao X,Bharti P,Thaivalappil A,Cao K
Peroxisomal abnormalities and catalase deficiency in Hutchinson-Gilford Progeria Syndrome.
Aging (Albany NY). 2020 Mar 18;12(6):5195-5208. doi: 10.18632/aging.102941. Epub 2020 Mar 18
Atchison L,Abutaleb NO,Snyder-Mounts E,Gete Y,Ladha A,Ribar T,Cao K,Truskey GA
iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome.
Stem Cell Reports. 2020 Feb 11;14(2):325-337. doi: 10.1016/j.stemcr.2020.01.005. Epub 2020 Feb 6
Sun L,Chiang JY,Choi JY,Xiong ZM,Mao X,Collins FS,Hodes RJ,Cao K
Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts.
Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):18983-18993. doi: 10.1073/pnas.1907199116. Epub 2019 Sep 3
Choi JY,Lai JK,Xiong ZM,Ren M,Moorer MC,Stains JP,Cao K
Diminished Canonical β-Catenin Signaling During Osteoblast Differentiation Contributes to Osteopenia in Progeria.
J Bone Miner Res. 2018 Nov;33(11):2059-2070. doi: 10.1002/jbmr.3549. Epub 2018 Aug 1
Wang K,Wu D,Zhang H,Das A,Basu M,Malin J,Cao K,Hannenhalli S
Comprehensive map of age-associated splicing changes across human tissues and their contributions to age-associated diseases.
Sci Rep. 2018 Jul 19;8(1):10929. doi: 10.1038/s41598-018-29086-2. Epub 2018 Jul 19