Graduate Program Affiliations

• BISI-Computational Biology, Bioinformatics, & Genomics (CBBG)
• BISI-Molecular & Cellular Biology (MOCB)

Research Interests

• Investigating the effects of missense single nucleotide variants on protein structure and function to elucidate their role in human disease
• Integrating knowledge of the biological mechanisms underlying the relationship between human genetic variation and disease, particularly complex trait diseases such as Alzheimer’s, diabetes, and Crohn’s disease
• Using novel neural network architectures derived from deep biological knowledge to probe aspects of disease mechanism, including the evaluation of potential drug targets and the best choice of drug for any patient, given their genome sequence
• Conducting large-scale community experiments to assess and advance the state of the art in areas of computational biology, particularly genome interpretation and protein structure modeling

Education

• D.Phil., Molecular Biophysics, University of Oxford, 1970
• B.Sc., Physics, University of London, 1965

All Publications