Brantley Hall headshot
Contact Info
Office: 3126 Bioscience Research Bldg.
Phone: 301-405-7481
Brantley Hall
Assistant Professor

Research Interests

The Hall lab studies the human gut microbiome with the goal of identifying the bacterial genes underlying health-relevant functions of the gut microbiome.  

Education

  • Ph.D., Virginia Tech, 2016. Genetics, Bioinformatics and Computational Biology
  • Postdoctoral Training, 2016-20, The Broad Institute of Harvard and MIT

All Publications

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Latest Publications

Jacoby C,Scorza K,Ecker L,McMillin M,Ramaswamy R,Sundararajan A,Sidebottom AM,Lin H,Dufault-Thompson K,Hall B,Jiang X,Light SH
Gut Bacteria Metabolize Natural and Synthetic Steroid Hormones via the Reductive OsrABC Pathway.
bioRxiv. 2024 Oct 9;:. pii: 2024.10.08.617280. doi: 10.1101/2024.10.08.617280. Epub 2024 Oct 9
Hall B,Levy S,Dufault-Thompson K,Arp G,Zhong A,Ndjite GM,Weiss A,Braccia D,Jenkins C,Grant MR,Abeysinghe S,Yang Y,Jermain MD,Wu CH,Ma B,Jiang X
BilR is a gut microbial enzyme that reduces bilirubin to urobilinogen.
Nat Microbiol. 2024 Jan;9(1):173-184. doi: 10.1038/s41564-023-01549-x. Epub 2024 Jan 3
Liu CM,Aziz M,Park DE,Wu Z,Stegger M,Li M,Wang Y,Schmidlin K,Johnson TJ,Koch BJ,Hungate BA,Nordstrom L,Gauld L,Weaver B,Rolland D,Statham S,Hall B,Sariya S,Davis GS,Keim PS,Johnson JR,Price LB
Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections.
One Health. 2023 Jun;16:100518. doi: 10.1016/j.onehlt.2023.100518. Epub 2023 Feb 28
Hall B,Levy S,Dufault-Thompson K,Ndjite GM,Weiss A,Braccia D,Jenkins C,Yang Y,Arp G,Abeysinghe S,Jermain M,Wu CH,Jiang X
Discovery of the gut microbial enzyme responsible for bilirubin reduction to urobilinogen.
bioRxiv. 2023 Feb 8;:. pii: 2023.02.07.527579. doi: 10.1101/2023.02.07.527579. Epub 2023 Feb 8
Braccia DJ,Minabou Ndjite G,Weiss A,Levy S,Abeysinghe S,Jiang X,Pop M,Hall B
Gut Microbiome-Wide Search for Bacterial Azoreductases Reveals Potentially Uncharacterized Azoreductases Encoded in the Human Gut Microbiome.
Drug Metab Dispos. 2023 Jan;51(1):142-153. doi: 10.1124/dmd.122.000898. Epub 2022 Sep 18
Dufault-Thompson K,Hall B,Jiang X
Taxonomic distribution and evolutionary analysis of the equol biosynthesis gene cluster.
BMC Genomics. 2022 Mar 5;23(1):182. doi: 10.1186/s12864-022-08426-7. Epub 2022 Mar 5
Yan W,Hall AB,Jiang X
Bacteroidales species in the human gut are a reservoir of antibiotic resistance genes regulated by invertible promoters.
NPJ Biofilms Microbiomes. 2022 Jan 10;8(1):1. doi: 10.1038/s41522-021-00260-1. Epub 2022 Jan 10
Braccia DJ,Jiang X,Pop M,Hall AB
The Capacity to Produce Hydrogen Sulfide (H(2)S) via Cysteine Degradation Is Ubiquitous in the Human Gut Microbiome.
Front Microbiol. 2021;12:705583. doi: 10.3389/fmicb.2021.705583. Epub 2021 Oct 20
Mou Z,Yang Y,Hall AB,Jiang X
The taxonomic distribution of histamine-secreting bacteria in the human gut microbiome.
BMC Genomics. 2021 Sep 26;22(1):695. doi: 10.1186/s12864-021-08004-3. Epub 2021 Sep 26
Brown EM,Arellano-Santoyo H,Temple ER,Costliow ZA,Pichaud M,Hall AB,Liu K,Durney MA,Gu X,Plichta DR,Clish CA,Porter JA,Vlamakis H,Xavier RJ
Gut microbiome ADP-ribosyltransferases are widespread phage-encoded fitness factors.
Cell Host Microbe. 2021 Sep 8;29(9):1351-1365.e11. doi: 10.1016/j.chom.2021.07.011. Epub 2021 Aug 16
Wilkinson JE,Franzosa EA,Everett C,Li C,HCMPH researchers and trainees,HCMPH investigators,Hu FB,Wirth DF,Song M,Chan AT,Rimm E,Garrett WS,Huttenhower C
A framework for microbiome science in public health.
Nat Med. 2021 May;27(5):766-774. doi: 10.1038/s41591-021-01258-0. Epub 2021 Apr 5
Yang Y,Yan W,Hall AB,Jiang X
Characterizing Transcriptional Regulatory Sequences in Coronaviruses and Their Role in Recombination.
Mol Biol Evol. 2021 Apr 13;38(4):1241-1248. doi: 10.1093/molbev/msaa281. Epub
Kenny DJ,Plichta DR,Shungin D,Koppel N,Hall AB,Fu B,Vasan RS,Shaw SY,Vlamakis H,Balskus EP,Xavier RJ
Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level.
Cell Host Microbe. 2020 Aug 12;28(2):245-257.e6. doi: 10.1016/j.chom.2020.05.013. Epub 2020 Jun 15
Yang Y,Yan W,Hall B,Jiang X
Characterizing transcriptional regulatory sequences in coronaviruses and their role in recombination.
bioRxiv. 2020 Jun 21;:. pii: 2020.06.21.163410. doi: 10.1101/2020.06.21.163410. Epub 2020 Jun 21
Nguyen LH,Ma W,Wang DD,Cao Y,Mallick H,Gerbaba TK,Lloyd-Price J,Abu-Ali G,Hall AB,Sikavi D,Drew DA,Mehta RS,Arze C,Joshi AD,Yan Y,Branck T,DuLong C,Ivey KL,Ogino S,Rimm EB,Song M,Garrett WS,Izard J,Huttenhower C,Chan AT
Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men.
Gastroenterology. 2020 Apr;158(5):1313-1325. doi: 10.1053/j.gastro.2019.12.029. Epub 2020 Jan 20
Sparks ME,Bansal R,Benoit JB,Blackburn MB,Chao H,Chen M,Cheng S,Childers C,Dinh H,Doddapaneni HV,Dugan S,Elpidina EN,Farrow DW,Friedrich M,Gibbs RA,Hall B,Han Y,Hardy RW,Holmes CJ,Hughes DST,Ioannidis P,Cheatle Jarvela AM,Johnston JS,Jones JW,Kronmiller BA,Kung F,Lee SL,Martynov AG,Masterson P,Maumus F,Munoz-Torres M,Murali SC,Murphy TD,Muzny DM,Nelson DR,Oppert B,Panfilio KA,Paula DP,Pick L,Poelchau MF,Qu J,Reding K,Rhoades JH,Rhodes A,Richards S,Richter R,Robertson HM,Rosendale AJ,Tu ZJ,Velamuri AS,Waterhouse RM,Weirauch MT,Wells JT,Werren JH,Worley KC,Zdobnov EM,Gundersen-Rindal DE
Brown marmorated stink bug, Halyomorpha halys (Stål), genome: putative underpinnings of polyphagy, insecticide resistance potential and biology of a top worldwide pest.
BMC Genomics. 2020 Mar 14;21(1):227. doi: 10.1186/s12864-020-6510-7. Epub 2020 Mar 14
Meccariello A,Salvemini M,Primo P,Hall B,Koskinioti P,Dalíková M,Gravina A,Gucciardino MA,Forlenza F,Gregoriou ME,Ippolito D,Monti SM,Petrella V,Perrotta MM,Schmeing S,Ruggiero A,Scolari F,Giordano E,Tsoumani KT,Marec F,Windbichler N,Arunkumar KP,Bourtzis K,Mathiopoulos KD,Ragoussis J,Vitagliano L,Tu Z,Papathanos PA,Robinson MD,Saccone G
Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests.
Science. 2019 Sep 27;365(6460):1457-1460. doi: 10.1126/science.aax1318. Epub 2019 Aug 29
Lloyd-Price J,Arze C,Ananthakrishnan AN,Schirmer M,Avila-Pacheco J,Poon TW,Andrews E,Ajami NJ,Bonham KS,Brislawn CJ,Casero D,Courtney H,Gonzalez A,Graeber TG,Hall AB,Lake K,Landers CJ,Mallick H,Plichta DR,Prasad M,Rahnavard G,Sauk J,Shungin D,Vázquez-Baeza Y,White RA 3rd,IBDMDB Investigators,Braun J,Denson LA,Jansson JK,Knight R,Kugathasan S,McGovern DPB,Petrosino JF,Stappenbeck TS,Winter HS,Clish CB,Franzosa EA,Vlamakis H,Xavier RJ,Huttenhower C
Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases.
Nature. 2019 May;569(7758):655-662. doi: 10.1038/s41586-019-1237-9. Epub 2019 May 29
Franzosa EA,Sirota-Madi A,Avila-Pacheco J,Fornelos N,Haiser HJ,Reinker S,Vatanen T,Hall AB,Mallick H,McIver LJ,Sauk JS,Wilson RG,Stevens BW,Scott JM,Pierce K,Deik AA,Bullock K,Imhann F,Porter JA,Zhernakova A,Fu J,Weersma RK,Wijmenga C,Clish CB,Vlamakis H,Huttenhower C,Xavier RJ
Author Correction: Gut microbiome structure and metabolic activity in inflammatory bowel disease.
Nat Microbiol. 2019 May;4(5):898. doi: 10.1038/s41564-019-0442-5. Epub
Franzosa EA,Sirota-Madi A,Avila-Pacheco J,Fornelos N,Haiser HJ,Reinker S,Vatanen T,Hall AB,Mallick H,McIver LJ,Sauk JS,Wilson RG,Stevens BW,Scott JM,Pierce K,Deik AA,Bullock K,Imhann F,Porter JA,Zhernakova A,Fu J,Weersma RK,Wijmenga C,Clish CB,Vlamakis H,Huttenhower C,Xavier RJ
Gut microbiome structure and metabolic activity in inflammatory bowel disease.
Nat Microbiol. 2019 Feb;4(2):293-305. doi: 10.1038/s41564-018-0306-4. Epub 2018 Dec 10