MPRI is primarily housed in the Biosciences Research Building (BRB) at the University of Maryland, College Park, where the entire top floor is dedicated to pathogen research. MPRI is administered through the Dept. of Cell Biology & Molecular Genetics (CBMG) in the College of Computational, Mathematical, and Natural Sciences (CMNS), but includes researchers from multiple Departments and Colleges at College Park. In particular MPRI has key synergistic ties on campus with Center for Bioinformatics and Computational Biology (CBCB) and the Department of Bioengineering. MPRI also has close ties with faculty at the Institute for Bioscience and Biotechnology Research (IBBR) located on its sister campus at Shady Grove.


CMNS also runs several multi-user core facilities that house and maintain high-end, state-of-the-art instrumentation vital to the research activities of a broad spectrum of MPRI investigators. These facilities include: Advanced Genomics Facility; Biological Imaging and Cell Sorting Facility; Proteomics and Mass Spectroscopy Facility; and Scientific Computing.


The close proximity of the University of Maryland to governmental agencies, including the National Institutes of Health, Food and Drug Administration, the Biodefense Laboratories at Fort Dietrick and Fort Meade, as well as top research facilities such as Johns Hopkins University, University of Maryland Biotechnology Institute (UMBI), National Children's Medical Center, University of Maryland School of Medicine, and over 300 biotechnology companies has greatly added to the strength and success of MPRI.